| 摘要 |
Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to one or more S. aureusstrains, including methicillin resistant S. aureusstrains, are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, n on- human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.</SDOA B>
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