发明名称 |
1,4-DIHYDROPYRIDINE DERIVATIVES |
摘要 |
<p>A 1,4-dihydropyridine derivative having the formula (I): <CHEM> wherein, R1 represents a substituted or unsubstituted phenyl or pyridyl group, R2 represents a C1 to C5 lower alkyl group, R3 represents a substituted or unsubstituted C1 to C8 alkyl, alkenyl, alkynyl or substituted or unsubstituted C3 to C7 cycloalkyl or cycloalkenyl group, R4 represents -A-R5, wherein A represents a C3 to C5 alkynylene group having one triple bond, and R5 represents a substituted or unsubstituted pyridyl, quinolyl, isoquinolyl or pyrimidyl group and a drug for overcoming resistance to an anti-cancer drug or a drug increasing the effect of an anti-cancer drug containing as an effective ingredient the derivative or its pharmacologically acceptable salt or hydrate.</p> |
申请公布号 |
EP1055672(A1) |
申请公布日期 |
2000.11.29 |
申请号 |
EP19990902821 |
申请日期 |
1999.02.03 |
申请人 |
NIKKEN CHEMICALS COMPANY, LIMITED |
发明人 |
TASAKA, SHIGEYUKI;KIUE, AKIRA;OMORI, HIROMASA;TANABE, HIROKAZU;GOMI, NORIAKI |
分类号 |
C07D401/12;C07D401/14;C07D409/14;C07D471/04;C07D521/00;(IPC1-7):C07D401/12;A61K31/535;A61K31/505;A61K31/495;A61K31/445 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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