发明名称 |
Process for preparaing (E)-methyl 2-[2-(6-(2-cyanophenoxy)-pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate in the absence of copper(salt) and of N,N-dimethylformamide |
摘要 |
PCT No. PCT/GB97/02793 Sec. 371 Date Jun. 10, 1999 Sec. 102(e) Date Jun. 10, 1999 PCT Filed Oct. 28, 1997 PCT Pub. No. WO98/18767 PCT Pub. Date May 7, 1998A process for preparing (E)-methyl 2-[2-(6-(-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate comprising contacting (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxypropenoate or methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropanoate with 2-cyanophenate anions, the process being conducted in the absence of copper or a copper salt and in the absence of N,N-dimethylformamide. The 2-cyanophenate anions are generated in situ by reacting 2-cyanophenol with an alkali metal carbonate.
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申请公布号 |
US6153750(A) |
申请公布日期 |
2000.11.28 |
申请号 |
US19990297169 |
申请日期 |
1999.06.10 |
申请人 |
ZENECA LIMITED |
发明人 |
WHITTON, ALAN JOHN;FLEMING, IAN GEORGE;EWINS, ROBERT COMGALL;JONES, RAYMOND VINCENT HEAVON;MCNEISH, SAMUEL |
分类号 |
C07D239/34;C07D239/52;(IPC1-7):C07D239/52 |
主分类号 |
C07D239/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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