| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain a new nucleotide compound which can be used as a starting raw material for forming nucleotide chains or as a basic constituting unit for enlarging chain lengths. SOLUTION: A compound of formula I [B is a nucleic acid base; R1, R2 are each H or an alkyl, cycloalkyl, aryl or aralkyl which may contain one or more heterogeneous atoms; R3 is a protecting group; R4 is H, hydroxyl group, an alkoxy or a trialkylsilyloxy; X is a dialkylamino, an azolyl or a saturated nitrogen-heterocyclic group; (n) is >=3; A is a divalent alkylene or a linear or branched alkylene which may contain one or more heterogeneous atoms]. For example, a phosphorazolide compound. The compound of formula I is obtained by reacting a compound of formula II with a compound of formula III in an inactive organic solvent such as tetrahydrofuran.</p> |
