| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the subject medicament exerting excellent anti-inflammatory effect, and useful for the therapy of diseases such as inflammatory diseases including myalgia, arthritis and rheumatism, and diseases including allergic dermatitis represented by atopic dermatitis and eczema, by including a specific diketopiperazine derivative as an active ingredient. SOLUTION: This medicament is obtained by including a diketopiperazine derivative composed of a condensed cyclized product of two amino acids, and pref. shown by the formula (m is 3 or 4; n is 0-2; R1 is a lower alkyl, OH, mercapto or the like; R2 is H, OH, an ether or the like) [e.g. cyclic (leucine- proline)] as an active ingredient. It is desirable that one of the above-mentioned amino acids is proline or a proline derivative. The above-mentioned derivative is obtained through the following steps; protecting the amino group of one of the amino acids, protecting the carboxylic acid group of the other amino acid, and binding the thus protected amino group to the thus protected carboxylic acid group followed by removing the protective groups to condense and cyclize both of the amino acids.</p> |
