发明名称 |
TagA gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma |
摘要 |
The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic polypeptide of the present invention and detecting the binding of the antigen or fragment and the antibody. The detection of a strain expressing the TagA antigen is an indication of predisposition to peptic ulceration and gastric carcinoma. A mutant H. pylori not expressing a functional TagA antigen is also provided.
|
申请公布号 |
US6153390(A) |
申请公布日期 |
2000.11.28 |
申请号 |
US19990259437 |
申请日期 |
1999.03.01 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
COVER, TIMOTHY L.;BLASER, MARTIN J.;KLEANTHOUS, HARRY;TUMMURU, MURALI K. R. |
分类号 |
G01N33/569;A61K38/00;A61K39/00;A61K39/106;A61P1/04;A61P35/00;C07K14/195;C07K14/205;C12N1/21;C12N15/09;C12N15/31;C12Q1/68;C12R1/01;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/569 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|