| 摘要 |
The vitamin D3 derivative or a diastereoisomer or mixture thereof has the formula I wherein: Q is methylene, ethylene or tri- tetra- or pentamethylene, -CH=CH-, -CH=CH-CH=CH-, -CH=CH-CH2-, -CºC-, -CºC-CH2-, -CH(R)-(CH2)2-, -CH(R)-CH=CH- or -CH(R)-CºC-; R is alkyl; Y is a single bond, a carbonyl group, methylene, ethylene, -CH(OH)-, -O-(C6H4)- or -S-(C6H4)- radical; R1 and R2 are independently hydrogen or a hydrocarbyl radical or R1 and R2 with the carbon atom to which they are attached (starred in formula I) can form a carbocyclic ring and Z is hydrogen or hydroxy; with the proviso that when Q is ethylene, Y is methylene, carbonyl or -CH(OH)-, R1 and R2 are methyl and Z is hydroxy, then the configuration at C-20 cannot be (R). Also disclosed as certain intermediate compounds having a 3(R)-bis-(tert-butyldimethylsilyoxy) radical. A pharmaceutical composition thereof is useful for treating or prophylaxis of psoriasis, cancer, myelofibrosis, rheumatoid arthritis, asthma, secondary hyperparathyroidism associated with renal failure or Alzheimer's disease.
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