Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue

摘要

flt3-ligand or flt3-L optionally with a cytokine is used in the manufacture of a medicament to a).increase the number of circulating progenitor cells or stem cells prior to cytoreductive therapy; b).facilitate the engraftment of any transplanted progenitor cells or stems cells in a patient when the patient is receiving or has received cytoreductive therapy; c).stimulating the proliferation of T cells in a mammal or cells of the eyrthroid lineage in the spleen of a mammal; d).administer to a patient receiving cytoreductive therapy; e).administer to a patient having the symptoms of myelodysplastic syndrome, anemia, and acquired immune deficiency syndrome. It can also be used to expand progenitor cells or stem cells ex vivo or transforming hematopoietic cells prior to or during transfection with an exogenous gene ex vivo. The cytokine can be CSF-1, EPO and IL-6.