摘要 |
Compounds of formula (I) may be used for preventing or treating disorders modulated by alpha-2 adrenoceptors. In formula (I); R1 is hydrogen, or alkyl or nil; provided that when R1 is nil, bond (a) is a double bond; D is CR2, where R2 is selected from hydrogen, unsubstituted C1-C3 alkanyl, amino, hydroxy, mercapto, C1-C3 alkylthio or alkoxy, C1-C3 alkylamino, C1-C3 dialkylamino and halo, or when B is CR3, D may be N; B is NR9, CR3=CR8, CR3=N, CR3, S, O, SO or SO2; wherein R9 is selected from hydrogen, unsubstituted C1-C3 alkanyl, alkenyl or alkynyl, cycloalkanyl and cycloalkenyl; and R3 and R8 are each independently selected from hydrogen, unsubstituted C1-C3 alkanyl, alkenyl or alkynyl, cycloalkanyl, cycloalkenyl, unsubstituted C1-C3 alkylthio or alkoxy, hydroxy, thio, nitro, cyano, amino, C1-C3 alkylamino or C1-C3 dialkylamino and halo; R4, R5 and R6 are each independently selected from hydrogen, unsubstituted C1-C3 alkanyl, alkenyl or alkynyl, cycloalkanyl, cycloalkenyl, unsubstituted C1-C3 alkylthio or alkoxy, hydroxy, thio, nitro, cyano, amino, C1-C3 alkylamino, C1-C3 dialkylamino, halo, and NH-NH-C(=NR10)NHR11 (guanidinylamino), wherein R10 and R11 are independently selected from hydrogen, methyl, and ethyl, and wherein only one of R4, R5 and R6 is guanidinylamino; and R7 is selected from hydrogen, unsubstituted C1-C3 alkanyl, alkenyl or alkynyl, cycloalkanyl, cycloalkenyl, unsubstituted C1-C3 alkylthio or alkoxy, hydroxy, thio, nitro, cyano, amino, C1-C3 alkylamino or C1-C3 dialkylamino and halo.
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