发明名称 |
Liquid alendronate formulations and their use in preventing bone resorption |
摘要 |
An aqueous liquid pharmaceutical formulation comprising: 1).alendronic acid or a pharmaceutically acceptable salt as an active ingredient; 2).a sufficient amount of a buffer such that: a) the pH of the formulation is between approximately 3.5 and approximately 7.5; and b) 15 ml of the formulation is able to raise the pH of 50 ml 0.1N HCl to a pH of at least 3; and optionally, one or more additional agents selected from the group consisting of preservatives, flavouring agents, colorants, and sweeteners. More particularly, the formulation comprises: (in mg/ml): alendronate monosodium trihydrate 0.2-0.9 (on an alendronic acid basis) sodium benzoate 1.0-2.0 sodium citrate dihydrate 75-125 citric acid, anhydrous 0.340 xylitol 100-640 Also disclosed is the use of alendronic acid as a medicament for inhibiting bone resorption.
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申请公布号 |
NZ334836(A) |
申请公布日期 |
2000.11.24 |
申请号 |
NZ19970334836 |
申请日期 |
1997.10.02 |
申请人 |
MERCK & CO |
发明人 |
NERURKAR, MANEESH J;HUNKE, WILLIAM A;OSTOVIC, DRAZEN |
分类号 |
A61K9/08;A61K9/00;A61K31/663;A61K47/12;A61K47/26;A61P19/10;(IPC1-7):A61K31/66 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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