| 摘要 |
A compound having a structure according to formula I in which the sugar is in an L conformation wherein, A is independently selected from N or C, B, C, E, F are independently selected from CH, CO, N, S, Se, O, NR1, CCONH2, CCH3, C-R2 or P, R1 is independently H, lower alkyl, lower alkylamines, COCH3, lower alkyl alkenyl, lower alkyl vinyl or lower alkyl aryls, R2 is independently H, OH, halogens, CN, N3, NH2, C(=O)NH2, C(=S)NH2, C(=NH)NH2.HCl, C(=NOH)NH2, C(=NH)OMe, lower alkyl, lower alkylamines, lower alkyl alkenyl, lower alkyl vinyl, lower alkyl aryls or substituted heterocycles, D is independently selected from CH, CO, N, S, Se, O, NR1, CCONH2, CCH3, C-R2, P or nothing, where R1 is independently H, O, lower alkyl, lower alkylamines, COCH3, lower alkyl alkenyl, lower alkyl vinyl or lower alkyl aryls, and R2 is independently H, OH, halogens, CN, N3, NH2, lower alkyl, lower alkylamines, lower alkyl alkenyl, lower alkyl vinyl, lower alkyl aryls or substituted heterocycles, X is independently O, S, CH2 or NR, where R is COCH3, R1 and R4 are independently selected from H, CN, N3, CH2OH, lower alkyl and lower alkyl amines, R2, R3, R5, R6, R7 and R8 are independently selected from H, OH, CN, N3, CH2OH, NH2, OCH3, NHCH3, ONHCH3, SCH3, SPh, alkenyl, lower alkyl, lower alkyl amines and substituted heterocycles with additional provisos as given in the specification. The abovementioned compounds are useful for inversely modulating Th1 and Th2 activities.
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