Substituted 3-thia-1,2,3,4-tetrahydrocarbazole, 6,7,8,9-tetrahydropyrido[1,2-a]indole, 4,5-dihydro-thiopyrano[3,4-b]indole, pyrano[3,4-b]indole or beta-carbolinyl derivatives

摘要

The indole derivatives or pharmaceutically acceptable salts thereof have the formula I wherein: A is phenyl or pyridyl; one of B or D is nitrogen and the other is carbon; Z is cyclohexyl, phenyl, pyridyl or a 6 membered heterocyclic ring having a heteroatom chosen from S, N or O; The dashed line is either a single or double bond; R20 is optionally substituted alkyl, alkenyl, alkynyl, carbocyclic or heterocyclic radical or is -(L)-R80; L is a divalent linking group of 1 to 12 atoms selected from carbon, hydrogen, oxygen, nitrogen and sulphur; R80 is optionally substituted alkyl, alkenyl, alkynyl, carbocyclic or heterocyclic radical; R21 is a non-interfering substituent; R1' is NHNH2, NH2 or CONH2; R2' is OH or O(CH2)-R5'; R3' is a non-interfering substituent, optionally substituted carboyclic radical or heterocyclic radicals and R5' is as defined in the specification provided that one of A or Z is a heterocyclic ring and when D is nitrogen, the heteroatom of Z is S or O in positions 1, 2 or 3 or N in positions 1, 2, 3 or 4. A pharmaceutical composition thereof is useful in treating sepsis, septic shock, rheumatoid arthritis, stroke, asthma, or pancreatitis.