发明名称 New racemic complexes of gadolinium with (1,4,7,10-tetra-azacyclododecane)-1,4,7,10-tetra-(2-glutaric) acid useful as magnetic resonance contrast agents
摘要 Racemic complexes (I) of gadolinium with (1,4,7,10-tetra-azacyclododecane)-1,4,7,10-tetra-(2-glutaric) acid and their base salts, are new. Racemic complexes of formula (I) of gadolinium with (1,4,7,10-tetra-azacyclododecane)-1,4,7,10-tetra-(2-glutaric) acid and their base salts, are new. R = phenyl or 1-8C alkyl (optionally hydroxylated), optionally interrupted by one or more phenyl, alkyl, oxy, amino, or amido optionally substituted by alkyl, with phenyl optionally substituted by OH, Br, Cl, I, 1-8C alkyl, 1-8C alkyleneoxy, NO2, NRxRy, NRxCORy, CONRxRy, COORx and Rx, Ry = H or 1-8C alkyl. An Independent claim is included for preparation of (I).
申请公布号 FR2793795(A1) 申请公布日期 2000.11.24
申请号 FR19990006517 申请日期 1999.05.21
申请人 GUERBET SA 发明人 ROUSSEAUX OLIVIER;SIMONOT CHRISTIAN
分类号 A61K49/04;A61K49/06;C07D257/02;(IPC1-7):C07F5/00 主分类号 A61K49/04
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