| 摘要 |
This method for treatment, diagnosis and prevention of a pathogen infection comprises administering to a patient antibodies which react with regions of proteins which fail to elicit an immune response in man when encountered through infection or naturally through the environment, but do elicit an immune response in non-human animals. The immunological non-responsiveness in man is thought to be a function of molecular mimicry and lack of MHC associated events. HIV proteins with the characteristics described above are selected as follows. HIV proteins are isolated from a lysate of an HIV strain, treated to remove HLA class I and class II antigens, and used to immunize a non-human mammal. The antisera from this mammal is employed in a competitive immunoassay with human HIV antisera to identify regions of HIV proteins which are recognized by antibodies in the mammal antisera, but not recognized by antibodies in the human antisera. Antibodies to the epitope from the immunized host may be administered to a patient to treat or prevent infection. Particular HIV1sF2 proteins investigated are: (a) envelope gp120 external glycoprotein; (b) envelope gp41 transmembrane glycoprotein; (c) reverse transcriptase; (d) protease p1O; or (e) gag precursor
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