| 发明名称 |
NEUROPROTECTIVE PROPERTIES OF GDF-15, A NOVEL MEMBER OF THE TGF-.BETA. SUPERFAMILY |
| 摘要 |
The present invention relates to a transforming growth factor-beta (TGF- .beta.)-like protein which is derived from neurons and glial cells, and whic h has a neurotrophic effect on dopaminergic (DAergic) neurons, to nucleic acid s coding for the protein, to a vector containing the nucleic acids, to host organisms containing the nucleic acids or the vector, to antibodies directed against the protein, to methods for the production of the nucleic acids, the vector or the protein, to a pharmaceutical composition for the treatment of neurodegenerative disorders in mammals and to a diagnostic kit for the detection of said disorders.
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| 申请公布号 |
CA2372119(A1) |
申请公布日期 |
2000.11.23 |
| 申请号 |
CA20002372119 |
申请日期 |
2000.05.16 |
| 申请人 |
BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG UND ZUM VERTRIE B V |
发明人 |
KRIEGELSTEIN, KERSTIN;UNSICKER, KLAUS |
| 分类号 |
G01N33/53;A61K31/7088;A61K35/76;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P25/00;A61P25/16;A61P25/18;A61P25/24;A61P25/28;A61P31/04;A61P43/00;C07K14/495;C07K16/22;C07K16/24;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/19;C12P19/34;C12P21/02;C12Q1/68;(IPC1-7):C12N15/19 |
主分类号 |
G01N33/53 |
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