发明名称 |
STABILIZATION AND ACOUSTIC ACTIVATION OF POLYMERIC MICELLES FOR DRUG DELIVERY |
摘要 |
Methods are disclosed in which a micelle is stabilized against degradation upon dilution. The micelle comprises molecules of a block polymer having a hydrophobic block and a hydrophilic block. The hydrophobic block forms a core of the micelle with corona from the hydrophilic block. The methods for stabilizing the core are (1) by chemically cross-linking, (2) incorporating a hydrophobic oil (vegetable oil) in the core to render it more hydrophobic and stable, and (3) incorporating a cross-linked interpenetrating network of a stimuli-responsive hydrogel into the core. The hydrogel is responsive to any stimuli, but preferably temperature or pH. A substance such as drugs can be incorporated into the dense inner core of the micelles. When subjected to ultrasound, the micelles release the substance, and then reversibly revert to a stable dense core and re-encapsulating the substance when the ultrasound is turned off. By pulsing the ultrasound, it is therefore, to controllably release the substance in a pulsed manner corresponding to the ultrasound signal.
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申请公布号 |
WO0069942(A1) |
申请公布日期 |
2000.11.23 |
申请号 |
WO2000US14081 |
申请日期 |
2000.05.19 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION;BRIGHAM YOUNG UNIVERSITY;RAPOPORT, NATALYA;PITT, WILLIAM, G. |
发明人 |
RAPOPORT, NATALYA;PITT, WILLIAM, G. |
分类号 |
A61K9/00;A61K9/107;A61K9/51;A61K9/52;C08F293/00;C08G65/32;C08L71/02;(IPC1-7):C08F293/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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