ADENOVIRUS DERIVED GENE DELIVERY VEHICLES COMPRISING AT LEAST ONE ELEMENT OF ADENOVIRUS TYPE 35

摘要

The serotypes differ in their natural tropism. The adenovirus serotypes (2, 4, 5 and 7) all have a natural affiliation towards lung epithelia and other respiratory tissues. In contrast, serotypes (40 and 41) have a natural affiliation towards the gastrointestinal tract. The serotypes described above, differ in at least capsid proteins (penton-base, hexon), proteins responsible for cell binding (fiber protein), and proteins involved in adenovirus replication. This difference in tropism and capsid protein among serotypes has led to the many research efforts aimed at redirecting the adenovirus tropism by modification of the capsid proteins.