COMBINATION THERAPY FOR TREATING HYPERCHOLESTEROLEMIA
摘要
The invention relates to methods for treating hypercholesterolemia and atherosclerosis, and reducing serum cholesterol in a mammal. The methods of the invention comprise administering to a mammal a first amount of a bile acid sequestrant compound which is an unsubstituted polydiallylamine polymer and a second amount of an HMG Co-A reductase inhibitor compound. The first and second amounts together comprise a therapeutically effective amount. The invention further relates to pharmaceutical compositions useful for the treatment of hypercholesterolemia and atherosclerosis, and for reducing serum cholesterol. The pharmaceutical compositions comprise a combination of a first amount of an unsubstituted polydiallylamine polymer compound and a second amount of an HMG Co-A reductase inhibitor compound. The first and second amounts comprise a therapeutically effective amount. The pharmaceutical compositions of the present invention may optionally contain a pharmaceutically acceptable carrier.
申请公布号
WO0069446(A1)
申请公布日期
2000.11.23
申请号
WO1999US10637
申请日期
1999.05.13
申请人
GELTEX PHARMACEUTICALS, INC.
发明人
HUVAL, CHAD, CORI;HOLMES-FARLEY, STEPHEN, RANDALL;PETERSEN, JOHN, S.;DHAL, PRADEEP, K.