SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USEAND PHARMACEUTICAL PREPARATIONS COMPRISING THEM

摘要

The present invention relates to spiroimidazolidine derivatives of formula ( I) in which E, V, W, X, R1 and R2 have the meanings indicated in the claims. Th e compounds of formula (I) are valuable pharmaceutical active compounds which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. Th e compounds of formula (I) are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to th e integrins group. They are generally suitable for the therapy and prophylaxis of illnesses which are caused by an undesired extent of leukocyte adhesion and/or leukocyte migration or are associated therewith or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 recepto rs with their ligands play a part. The invention furthermore relates to process es for the preparation of the compounds of formula (I), their use and pharmaceutical preparations which contain compounds of formula (I).