COMPOSITIONS OF SOLVENTS AND HIGH CONCENTRATIONS OF NUCLEIC ACID ANALOGS
摘要
The invention provides compositions and methods suitable for dissolving nucleic acid analogs with uncharged, neutral backbones at high concentrations at approximately neutral pH. By using the compositions of the invention, which include a polar, aprotic solvent, concentrations of nucleic acid analogs such as PNA can be achieved in the range of approximately 1 mu M to 10 mM.
申请公布号
WO0069899(A1)
申请公布日期
2000.11.23
申请号
WO2000US13227
申请日期
2000.05.11
申请人
THE PERKIN-ELMER CORPORATION;BLOCH, WILL;WERNER, WILLIAM, E.;EGHOLM, MICHAEL;MYERS, RENE, L.
发明人
BLOCH, WILL;WERNER, WILLIAM, E.;EGHOLM, MICHAEL;MYERS, RENE, L.