POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES ENCODING MURINE ORGANIC ANION TRANSPORTER 5 (mOATP5) AND SCREENING METHODS THEREOF

摘要

Mouse OATP5 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize mouse OATP5. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: cancer, inflammation, cardiovascular disease, central nervous system disorders, auto-immune disease, and kidney and liver disease.