(E,3R)-ENANTIOMER OF 4-(3-CHLORO -4-CYANOPHENYL) -1-(P- METHYLSULPHONYL -PHENYLSULPHONYL) -2-TRIFLUOROMETHYLBUT -TRANS-3-EN-OL

摘要

The present invention relates to an (E,3R)-enantiomer of Formula (I) or a pharmaceutically-acceptable salt or in vivo-cleavable ester or ether thereof, substantially free of the enantiomeric (E,3S)-compound. The compound is a peripherally-selective antiandrogen. The invention also relates to a crystalline form of the enantiomer or the salt, ester or ether thereof. In addition, the present invention relates to a process for the preparation of all of these compounds, a pharmaceutical composition comprising the enantiomer, salt, ester, ether or crystalline form, and uses and methods employing the enantiomer, salt, ester, ether or crystalline form.