LIPOSOME COMPOSITION CONTAINING SELEGILIN, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION WITH MONOAMINOOXIDASE- INHIBITING ACTIVITY

摘要

pharmaceutical chemistry. SUBSTANCE: composition contains, wt %: active ingredient selegilin, i.e. (-)-N-(dimethyl-N-(2-propylphenylethylamine), and/or its salts, 0.1-40; lipids, preferably phospholipids, 2-40; cholesterol, 0-10; ethanol, 0-20; ethylene glycol, 0-25; antioxidant, 0-3; preservative, 0-3; viscosity- modifying agent, 0-2; cyclodextrine or its derivative, 0-50; water, 30-90. Composition can be administered for treatment of Alzheimer disease, Parkinson disease, depression, paralysis, locomotor disorders, and myelitis. EFFECT: enhanced therapeutic efficiency. 17 cl, 9 dwg, 1 tbl, 6 ex