发明名称 |
Anti-microbial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components |
摘要 |
This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphorfructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors. A cDNA sequence that encodes chorismate synthase expressed at an early state of Apicomplexan development, is disclosed and may be altered to produce a "knockout" organism useful in vaccine production. |
申请公布号 |
AU4676000(A) |
申请公布日期 |
2000.11.17 |
申请号 |
AU20000046760 |
申请日期 |
2000.04.27 |
申请人 |
ARCH DEVELOPMENT CORPORATION;PIOTRI GORNICKI;ELLEN ZUTHER;MRJ TRUST;RIMA W. MCLEOD;CRAIG ROBERTS;FIONA ROBERTS;JENNIFER JOHNSON;MICHAEL KIRISITS;DAVID FERGUSON;RUSSELL LYONS;ERNEST MUI;ROBERT HASELKORN;DOUG MACK;BENJAMIN SAMUEL |
发明人 |
RIMA W. MCLEOD;CRAIG ROBERTS;FIONA ROBERTS;JENNIFER JOHNSON;MICHAEL KIRISITS;DAVID FERGUSON;RUSSELL LYONS;ERNEST MUI;ROBERT HASELKORN;DOUG MACK;BENJAMIN SAMUEL;PIOTRI GORNICKI;ELLEN ZUTHER |
分类号 |
A61K39/002;A61P37/02;C12N15/60;C12Q1/18 |
主分类号 |
A61K39/002 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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