NOVEL G-PROTEIN MODULATOR (GPM) PROTEINS AND NUCLEIC ACID MOLECULES AND USES THEREFOR

摘要

Novel G protein modulator (GPM) polypeptides, proteins, and nucleic acid molecules are disclosed, which stimulate G protein activity in a receptor-independent manner. In addition to isolated, full-length GPM proteins, the invention further provides isolated GPM fusion proteins, antigenic peptides and anti-GPM antibodies. The invention also provides GPM nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a GPM gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.