| 摘要 |
The present invention relates to rapid, specific, high through-put assays for screening test substances for their ability to modulate activity of an ATPase involved in a variety of biological processes such as regulation of osmotic balance and cell volume, maintenance of the resting membrane potential, establishment of the ionic composition of cerebrospinal fluid and aqueous humor, electrical activity of muscle and nerve, and receptor-mediated endocytosis. The assays can be used to identify compounds for use in therapeutic applications to disease processes in which dysfunction of the ATPase contributes to a pathological process. The present invention also provides kits that can be used in the assays. |
