| 摘要 |
Tetrapeptide L-alanyl-L-gluthamyl-L-asparagyl-glycine of the general formula L- Ala-L-Glu-L-Asp-Gly is proposed as a biologically active compound revealing a geroprotective effect. The use of L-Ala-L-Glu-L-Asp-Gly tetrapeptide in medicine is proposed for preparing a substance revealing a geroprotective effect. There is proposed a pharmacological substance, which contains as its active base an effective amount of tetrapeptide of the formula L-alanyl-L- gluthamyl-L-asparagyl-glycine (L-Ala-L-Glu-L-Asp-Gly) or its salts of the amino group (acetate, hydrochloride, oxalate) and of carboxyl groups (the salts of metals - Natrium, Potassium, Calcium, Lithium, Zinc, Magnesium, and also the salts of organic and inorganic cations - ammonium and triethylammonium). The substance is proposed for parenteral, intranasal, ora l administration, and local application. With respect to the invention, the method of premature ageing prevention implies prophylactic and/or therapeuti c administration to a patient of the pharmacological substance in doses 0.01 t o 100 .mu.g/kg of the body weight at least once a day for a period necessary f or the achievement of a therapeutic effect.
|
