| 摘要 |
<p>The present invention provides a method for modulating, controlling or regulating intraocular pressure and secretion of the aqueous humor of the eye, in particular for treating or reducing elevated intraocular pressure or secretion, e.g., related to glaucomas. Using continuously cultured ciliary epithelial cells, the present invention provides characterization of the sodium/proton exchanger (antiport) which functions together with the chloride/bicarbonate exchanger (antiport) in the critical first step of the secretion of the aqueous humor, wherein fluids and salts are taken up from the stroma. In particular, the relevant sodium/proton exchanger has now, for the first time, been identified as the NHE-1 member of the family of sodium/proton exchangers. This discovery is particularly relevant because of the known sensitivity of the exchanger to a number of modulating drugs or compounds, which are effective at very low concentrations. Consequently, in accordance with the present invention, control of the exchanger permits the reversible control or regulation of the secretion of the aqueous humor, permitting the prevention or modulation of the fluid in the intraocular space.</p> |
