| 发明名称 |
STEREOSELECTIVE ANTIFIBRILLOGENIC PEPTIDES AND PEPTIDOMIMETICS THEREOF |
| 摘要 |
The present invention relates to antifibrillogenic agents for inhibiting amyloidosis and/or for cytoprotection for the treatment of amyloidosis disorders. These agents include peptides, isomers thereof and peptidomimetic compounds thereof. These agents comprise a peptide having a sequence identified from the glycosaminoglycan (GAG) binding region and the prot-prot interaction region of the amyloid protein. The peptide has at least one [D] amino acid isomer substitution. The invention also relates to the peptide bound to a label for <i>in vivo</i> imaging of amyloid deposits.
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| 申请公布号 |
WO0068263(A2) |
申请公布日期 |
2000.11.16 |
| 申请号 |
WO2000CA00515 |
申请日期 |
2000.05.04 |
| 申请人 |
NEUROCHEM, INC.;CHALIFOUR, ROBERT;GERVAIS, FRANCINE;GUPTA, AJAY |
发明人 |
CHALIFOUR, ROBERT;GERVAIS, FRANCINE;GUPTA, AJAY |
| 分类号 |
C12N5/06;A61K38/00;A61K49/00;A61P19/02;A61P25/00;A61P25/28;A61P29/00;A61P31/06;A61P35/00;C07K5/093;C07K5/11;C07K5/117;C07K7/06;C07K14/47;(IPC1-7):C07K14/47;A61K38/17;G01N33/68;C12N5/00;A61K51/00 |
主分类号 |
C12N5/06 |
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