This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as well as recovery and purification of the immunogenic peptides from recombinant organisms. The invention is also directed to methods of vaccination against botulism using the expressed peptides.
申请公布号
WO0067700(A2)
申请公布日期
2000.11.16
申请号
WO2000US12890
申请日期
2000.05.12
申请人
UNITED STATES ARMY MEDICAL RESEARCH & MATERIEL CMD;SMITH, LEONARD, A.;BYRNE, MICHAEL, P.;MIDDLEBROOK, JOHN, L.;LAPENOTIERE, HUGH
