| 摘要 |
This invention relates to compounds of general formula (I): or a pharmaceutically acceptable salt thereof, W, T, Y, X, Q, R<1>, R<2>, and R<3> are defined herein. This invention also relates to compounds of formula (I), depicted above, wherein Y is -NH-; T is (2S,3S)-2-phenylpiperidin-3-yl, where the phenyl group of said (2S, 3S)-2-phenylpiperidine-3-yl may optionally be substituted with fluoro; Q is oxygen and is double bonded to the carbon atom to which it is attached, X is methoxy or ethoxy, R<1> is hydrogen, methyl or halo-C1-C2 alkyl, W is methylene, ethylene or vinylene; R<2> and R<3> are independently hydrogen or methyl, or one of R<2> or R<3> may be hydroxy, when W is ethylene, R<2> and R<3> are both methyl, when W is methylene, and R<2> and R<3> are both hydrogen, when W is vinylene. The invention is further directed to methods of treating various CNS and other disorders using said compounds and pharmaceutical compositions thereof.
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