| 摘要 |
<p>The present invention relates to a process for the preparation of 1-[3-cyclopentyl-2(R)-[1(R)-(hydroxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)-ethyl]propionyl]piperidine (1), characterised in that the process comprises adding a carboxylic acid to the solution of the reaction mixture during or after the last reaction step yielding compound (1), which acid is other than a starting material for the last reaction step, and before partial or complete evaporation of the solvent in said solution takes place.</p> |
