| 发明名称 |
PROTEIN HAVING TPO ACTIVITY |
| 摘要 |
The present invention relates to thrombopoietin (TPO) polypeptides having the biological activity of specifically stimulating or increasing platelet production comprising the amino acid sequence 1-332 of SEQ ID NO: 6 or a derivative thereof, DNA molecules encoding TPO polypeptides, processes for production of the polypeptides, antibodies specifically immunoreactive with the polypeptides, pharmaceutical compositions comprising the polypeptides, and methods for using the polypeptides in treatment of platelet disorders such as thrombocytopenia. |
| 申请公布号 |
KR100272867(B1) |
申请公布日期 |
2000.11.15 |
| 申请号 |
KR19977002400 |
申请日期 |
1997.04.12 |
| 申请人 |
KIRIN BEER KABUSHIKI KAISHA |
发明人 |
MIYAZAKI, HIROSHI;KATO, TAKASHI;OHGAMI, KINYA;IWAMATSU, AKIHIRO;AKAHORI, HIROMICHI;KUROKI, RYOTA;SHIMIZU, TOSHIYUKI;MUTO, TAKANORI |
| 分类号 |
C12N15/09;A61K;A61K38/00;A61K38/17;A61K38/18;A61K38/19;A61K38/22;A61K38/36;A61K39/395;A61P;A61P7/00;A61P7/02;A61P7/04;A61P9/00;A61P43/00;C07K;C07K14/435;C07K14/47;C07K14/475;C07K14/52;C07K14/575;C07K14/745;C07K16/18;C07K16/22;C07K16/24;C07K16/26;C07K16/36;C12N;C12N1/21;C12N5/10;C12N15/11;C12N15/12;C12N15/19;C12N15/62;C12N15/63;C12P21/02;C12R1/19;C12R1/91;G01N33/53 |
主分类号 |
C12N15/09 |
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