Derivatives of 3-amino-3-arylpropan-1-ol, process of their preparation, medicaments in which these substances are comprised and their use

摘要

3-Amino-3-(hetero)aryl-propan-1-ol derivatives (I) are new. The 3-amino-3-(hetero)aryl-propan-1-ol derivatives are compounds of formula (I), including their enantiomers and diastereoisomers, and their addition salts. A = aryl optionally containing hetero atoms and/or optionally substituted; R<1>, R<2> = 1-6C alkyl; or R<1> + R<2> = form 2-6C alkylidene optionally substituted with phenyl; R<3> = 3-6C alkyl, 3-6C cycloalkyl, aryl (optionally containing hetero atoms and optionally substituted with R<6>-R<8>) or a group of formula (i); R<4>, R<5> = 1-6C alkyl, 3-6C cycloalkyl, phenyl, benzyl or phenethyl; or R<4> + R<5> = form 3-6C alkylidene or -CH2CH2OCH2CH2-; R<6>-R<8> = H, F, Cl, Br, CHF2, CF3, OH, OCF3, OR<14>, NR<15>R<16>, SR<14>, phenyl, SO2CH3, SO2CF3, 1-6C alkyl, CN, COOR<14> or CONR<15>R<16>; or R<6> + R<7> = form -OCH2O-, -OCH2CH2O-, -CH=CHO-, -CH=C(CH3)O- or -(CH2)4-; R<14> = 1-6C alkyl, phenyl, benzyl or phenethyl; R<15>, R<16> = H, 1-6C alkyl, phenyl, benzyl or phenethyl; n = 1-3; 1-benzyl-2-(dimethylaminophenylmethyl)cyclohexanol and its reaction product with CH3I are excluded. An Independent claim is also included for the preparation of compounds (I).