2-CHLORO-3-PHENYLAMINO-5-HYDROXY-1,4-NAPHTHALENEDIONE DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF

摘要

PURPOSE: Novel 2-chloro-3-phenylamino-5-hydroxy-1,4-naphthalenedione derivatives as new 1,4-naphthalenedione derivatives having excellent platelet aggregation inhibiting capability and process for the preparation thereof are provided which can be used as a platelet aggregation inhibitor useful in the clinical detection. CONSTITUTION: Novel 2-chloro-3-phenylamino-5-hydroxy-1,4-naphthalenedione derivatives of formula (1) and a platelet aggregation inhibitor containing the same as an effective component are provided. In formula, R1, R2, R3 are the same or different H, F, Cl, Br, CH3CO, NO2, CF3 or C2H5OCO. The substance is orally administered at a daily dose of 2.5 to 100mg for adults (60kg).