CYCLIN DEPENDENT KINASE INHIBITORS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

摘要

PURPOSE: New cycline dependent kinases inhibitors, their pharmaceutically acceptable salt, hydrates and solvates are provided which have high anticancer effects by inhibiting CDKs activity and are also useful in the treatment of neurodegenerative diseases. CONSTITUTION: A compound of formula 1, which can act as inhibitors of cyclin dependent kinases (CDK's) and be used as therapeutic compounds for the treatment of tumors or other cell proliferation disorders, for example, cancer is described. In formula, R1 represents a substituted or nonsubstituted alkyl, aryl, heteroaryl, aminoalkyl, aminoaryl or aminoacyl group, Y represents SO2 or CO, R2 represents H or alkyl group, R3 represents H, halogen, hydroxy, amino or alkyl.