发明名称 |
Identification of the progression elevated gene-3 and uses thereof |
摘要 |
This invention provides an isolated nucleic acid molecule encoding a Progression Elevated Gene-3 protein. This invention also provides isolated nucleic acid molecule encoding a human Progression Elevated Gene-3 protein. This invention provides a nucleic acid molecule of at least 12 nucleotides capable of specifically recognizing a nucleic acid molecule encoding a Progression Elevated Gene-3 protein. This invention provides a method of detecting expression of the Progression Elevated Gene-3 in a sample. This invention provides an isolated nucleic acid molecule encoding a Progression Elevated Gene-3 protein operatively linked to a regulatory element. This invention provides a host vector system for the production of a polypeptide having the biological activity of a Progression Elevated Gene-3 protein. This invention also provides a purified Progression Elevated Gene-3 protein and a fragment thereof. This invention provides an antibody capable of specifically binding to a Progression Elevated Gene-3 protein. This invention provides a method for determining whether cells are in progression. This invention provides a method for diagnosing the aggressiveness of cancer cells by measuring the expression of Progression Elevated Gene-3. Finally, this invention provides various uses of the Progression Elevated Gene-3, its protein and the antibody against its protein.
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申请公布号 |
US6146877(A) |
申请公布日期 |
2000.11.14 |
申请号 |
US19970821818 |
申请日期 |
1997.03.21 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
FISHER, PAUL B. |
分类号 |
C07K14/47;C12N15/12;G01N33/574;G01N33/68;(IPC1-7):C07H21/00;C12N5/10;C12N15/63 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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