发明名称 |
Caspase inhibitors and the use thereof |
摘要 |
The present invention is directed to novel dipeptide thereof, represented by the general Formula I:where R1-R3, X and Y are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs. |
申请公布号 |
AU4213500(A) |
申请公布日期 |
2000.11.14 |
申请号 |
AU20000042135 |
申请日期 |
2000.04.07 |
申请人 |
CYTOVIA, INC.;SUI XIONG CAI;ECKARD WEBER;YAN WANG;GORDON B MILLS;DOUGLAS R. GREEN |
发明人 |
CYTOVIA, INC. |
分类号 |
C12N9/99;A61K38/00;A61P1/02;A61P1/04;A61P1/08;A61P1/16;A61P1/18;A61P3/10;A61P7/00;A61P7/06;A61P7/08;A61P9/04;A61P9/10;A61P13/10;A61P13/12;A61P15/08;A61P17/02;A61P17/06;A61P17/14;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P25/32;A61P27/02;A61P27/06;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P35/00;A61P37/00;A61P37/02;A61P39/02;A61P43/00;C07C237/22;C07C271/22;C07C311/19;C07D295/205;C07D311/16;C07D311/66;C07K5/06;C12N1/16 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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