| 摘要 |
PCT No. PCT/IB98/00493 Sec. 371 Date Oct. 15, 1999 Sec. 102(e) Date Oct. 15, 1999 PCT Filed Apr. 6, 1998 PCT Pub. No. WO98/47875 PCT Pub. Date Oct. 29, 1998An improved process, and intermediates, for the preparation of 4'-trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4-tetrahydro-isoquinoline-6-yl) amide (I), are disclosed. Compound (I) is useful as an inhibitor of microsomal triglyceride transfer protein and/or apolipoprotein B secretion, and which are accordingly useful for the preparation and treatment of atherosclerosis and its clinical sequelae, for lowering serum lipids, and related diseases.
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