Antiviral pyrimidinedione derivatives and process for the preparation thereof

摘要

The present invention relates to pyrimidinedione derivatives of following formula (I) which are useful as antiviral agents, especially as agents for treatment of AIDS, pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical compositions containing the same, wherein R represents cyclopropyl; cyclobutyl; cyclohexyl; unsubstituted or mono-, di- or trisubstituted phenyl with a group selected from hydroxy, C₁-C₄ alkyl, C₁-C₄ alkoxy, halogen, trifluoromethyl, cyano and amino; 1- or 2-naphthyl; 9-anthracenyl; 2-anthraquinonyl; unsubstituted or substituted pyridyl with a group selected from C₁-C₄ alkyl, C₁-C₄ alkoxy, cyano and halogen; 2-, 3- or 4-quinolinyl; oxiranyl; 1-benzotriazolyl; 2-benzoxazolyl; furanyl substituted with C₁-C₄ alkoxycarbonyl; C₁-C₄ alkylcarbonyl; or benzoyl, R₁ represents halogen or C₁-C₄ alkyl, R₂ and R₃ represent independently hydrogen or C₁-C₄ alkyl, X represents oxygen atom, and Y represents oxygen atom, sulfur atom or carbonyl.