发明名称 |
Isolated tumor rejection antigen precursor mage-2 derived peptides and uses thereof |
摘要 |
The invention describes peptides derived from tumor rejection antigen precursor MAGE-2. These peptides bind with HLA-A2 molecules, thus presenting complexes which provoke cytolytic T cell production. The resulting "CTLs" are specific for complexes of HLA-A2 and the peptide. The complexes can be used to generate monoclonal antibodies. The cytolytic T cells produced may be used in the context of immunotherapy, such as adoptive transfer.
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申请公布号 |
US6147187(A) |
申请公布日期 |
2000.11.14 |
申请号 |
US19980007748 |
申请日期 |
1998.01.15 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
MELIEF, CORNELIS J. M.;VISSEREN, M. W.;KAST, W. M.;VAN DER BRUGGEN, PIERRE;BOON-FALLEUR, THIERRY |
分类号 |
C12P21/08;A61K35/26;A61K38/00;A61K38/04;A61K39/00;A61K39/395;A61P35/00;A61P37/00;C07K5/00;C07K7/06;C07K7/08;C07K14/47;C07K14/705;C07K14/74;C07K16/28;C12N5/00;(IPC1-7):A61K38/04 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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