AROYLPIPERIDINE DERIVATIVES OR THEIR SALTS, PHARMACEUTICAL PREPARATION BASED ON THEM, AND METHOD OF PREPARATION THEREOF

摘要

biologically- active compounds. SUBSTANCE: invention provides novel aroylpiperidine derivatives with general formula I: (I), wherein X and Y represent, independently of each other, nitrogen atom or CH group and ring A is unsubstituted or substituted benzene ring, and their salts. Compounds manifest antagonistic activity toward the substance P and can be used in treatment of migraines and central nervous system disorders such as phobias, vomiting, schizophrenia, and depression. EFFECT: increased assortment of neuroleptics. 4 cl, 10 ex