Inhibitors of c-jun n-terminal kinases (jnk)

摘要

The present invention relates to compounds of formula (I) or (II), or a pharmaceutically acceptable derivative or prodrug thereof; wherein Y is selected from -(CH2)-Q1; -(CO)-Q1; -(CO)NH-Q1; -(CO)-O-Q1; -(SO2)-Q1 or -(SO2)NH-Q1; Q1 is a C1-C6 straight chain or branched alkyl or alkenyl group; a 5-7 membered aromatic or non-aromatic carbocyclic or heterocyclic ring; or a 9-14 membered bicyclic or tricyclic aromatic or non-aromatic carbocyclic or heterocyclic ring system, W is N or C; Z is CH or N, which are inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.