CYCLIC AMIDE COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

摘要

Compounds of general formula (I) or salts thereof, which exhibit excellent CCR5 antagonism and are useful as preventive or therapeutic drugs for HIV infection of human peripheral blood monocytes, particularly AIDS. In said formula R1 is hydrocarbyl and R2 is hydrocarbyl having two or more carbon atoms, or R?1 and R2¿ together with the nitrogen atom adjacent thereto may form a ring which may be substituted; R3 is optionally substituted hydrocarbyl or a heterocyclic group; R4 is hydrogen, hydrocarbyl, a heterocyclic group, or the like; E is a divalent chain hydrocarbon group or the like; G is CO or SO¿2?; J is nitrogen, a methyne group, or the like; and Q and R are each a divalent C1-C3 chain hydrocarbon group or the like.