发明名称 |
6-[[(ARYL AND HETEROARYL)OXY] METHYL]NAPHTHALENE -2-CARBOXIMIDAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF |
摘要 |
The invention concerns compounds of general formula (I) wherein: R1 represents either a hydrogen atom, or an amino group, or a C1-C4 alkyl group, or a C1-C6 alkoxycarbonyl group, or a -OH group; R2 represents either a C1-C6 alkyl group, or a phenyl or benzyl group, or a -CH2Q group, wherein Q is a heterocyclic group; R3 and R5 represent independently of each other for example either a hydrogen atom, or a C1-C4 alkyl group, or a -COOH group; R4 represents either a hydrogen atom, or a C1-C4 alkyl group, or a -(CH2)p-COOR8 group; Z represents either a -CH- group, or a nitrogen atom. The invention also concerns the methods of preparation and therapeutic use of said compounds. |
申请公布号 |
WO0066545(A1) |
申请公布日期 |
2000.11.09 |
申请号 |
WO2000FR01087 |
申请日期 |
2000.04.25 |
申请人 |
SANOFI-SYNTHELABO;ALCOUFFE, CHANTAL;BELLEVERGUE, PATRICE;DELLAC, GENEVIEVE;LATHAM, CHRISTOPHER;LASSALLE, GILBERT;MALLART, SERGIO;MARTIN, VALERIE;MASSON, CHRISTINE;MCCORT, GARY |
发明人 |
ALCOUFFE, CHANTAL;BELLEVERGUE, PATRICE;DELLAC, GENEVIEVE;LATHAM, CHRISTOPHER;LASSALLE, GILBERT;MALLART, SERGIO;MARTIN, VALERIE;MASSON, CHRISTINE;MCCORT, GARY |
分类号 |
C07D317/58;A61K31/155;A61K31/17;A61K31/18;A61K31/357;A61K31/36;A61K31/381;A61K31/425;A61K31/426;A61K31/44;A61K31/4406;A61K31/4409;A61K31/455;A61K31/4704;A61P7/00;A61P7/02;A61P7/10;A61P9/00;A61P9/10;A61P31/04;C07B53/00;C07C257/18;C07C275/24;C07C275/26;C07C279/16;C07C311/04;C07C311/07;C07C311/08;C07C311/09;C07C311/13;C07C311/27;C07C311/35;C07C317/28;C07C317/32;C07C323/44;C07D213/34;C07D213/40;C07D213/68;C07D213/76;C07D213/79;C07D213/80;C07D215/08;C07D215/22;C07D215/227;C07D277/24;C07D277/26;C07D277/28;C07D295/26;C07D319/18;C07D333/20 |
主分类号 |
C07D317/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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