发明名称 |
A BIOACTIVE AGENT DELIVERING SYSTEM COMPRISED OF MICROPARTICLES WITHIN A BIODEGRADABLE TO IMPROVE RELEASE PROFILES |
摘要 |
A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bio-active agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.
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申请公布号 |
WO0066085(A1) |
申请公布日期 |
2000.11.09 |
申请号 |
WO2000US11387 |
申请日期 |
2000.04.28 |
申请人 |
MACROMED, INC. |
发明人 |
SHIH, CHUNG;ZENTNER, GAYLEN, M. |
分类号 |
A61K9/06;A61K47/34;(IPC1-7):A61K9/14;A61F2/00 |
主分类号 |
A61K9/06 |
代理机构 |
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