发明名称 |
CHEMICAL PROCESSES |
摘要 |
(57) Abstract The invention relates to a process for the preparation of a compound of formula (I): wherein, R<1> represents C1-4 alkoxy; fluorine, chlorine or bromine; and R<2> represents hydrogen or C1-4 alkoxy; which process comprises the reaction of the corresponding orthonitrohalobenzene of formula (II): wherein R<1> and R<2> are as hereinbefore defined and X represents a fluorine, chlorine or bromine atom, with, when X represents a fluorine atom: a) an alkali metal cyanide, in a non aqueous solvent optionally in the presence of a catalyst; or when X represents a chlorine atom: b) cuprous cyanide and a source of bromide selected from hydrogen bromide, bromine and a tetraalkylammonium bromide; optionally in the presence of an alkali metal bromide or an alkaline earth metal bromide; or c) an alkali metal cyanide or a tetraalkylammonium cyanide, in the presence of an alkali metal bromide or an alkaline earth metal bromide; or c) an alkali metal cyanide or a tetraalkylammonium cyanide, in the presence of cuprous bromide and a phase transfer catalyst; or d) cuprous cyanide and lithium iodide; or when X represents a bromine atom: e) cuprous cyanide optionally in the presence of a catalyst selected from an alkali metal bromide or an alkaline earth metal bromide; or f) an alkalie metal cyanide in the presence of a catalytic amount of cuprous cyanide and a phase transfer catalyst. |
申请公布号 |
WO0021922(A3) |
申请公布日期 |
2000.11.09 |
申请号 |
WO1999EP08135 |
申请日期 |
1999.10.11 |
申请人 |
AVENTIS CROPSCIENCE S.A.;CASADO, MICHEL;RATTON, PATRICK;STEPHAN, DOMINIQUE;VIAUVY, AGNES |
发明人 |
CASADO, MICHEL;RATTON, PATRICK;STEPHAN, DOMINIQUE;VIAUVY, AGNES |
分类号 |
C07B61/00;C07C201/12;C07C205/12;C07C253/14;C07C255/49;C07C255/50 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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