PROCESSES FOR THE PREPARATION OF PIPERIDYLMETHYLPYRIDINE DERIVATIVES

摘要

A process for the preparation of compound (I) or salts thereof, characterized by reacting a compound of general formula (II) or a salt thereof with a compound of general formula (III) or a salt thereof under reducing conditions to obtain a compound of general formula (IV) or salts thereof, reacting this compound or this salt with an aminating agent to obtain a compound of general formula (V) or a salt thereof, freeing at need the compound (V) or the salt thereof from the amino-protecting group of R<1> and the amino substituent of R<2> to obtain compound (VI) or a salt thereof, condensing the compound (V) or (VI) or the salt thereof with compound (VII), and removing the substituent of R<2> when R<2> is substituted amino; intermediates (I) and (V) for the process; and processes for the preparation of the intermediates wherein R<1> is optionally protected amino; R<2> is optionally substituted amino; and X is halogeno.