NUCLEIC ACIDS AND POLYPEPTIDES DERIVED FROM ACTIVATED EOSINOPHIL CELLS AND USE THEREOF

摘要

This invention relates to the immune response activity of eosinophils, and especially activated eosinophils, and provides isolated nucleic acids, polypeptides, including fragments, subunits and variants of the nucleic acids and polypeptides, as well as related compositions, probes, vectors, host cells, antibodies, and methods. In one aspect, the invention provides isolated nucleic acids encoding specific eosinophil-derived polypeptides or fragments or variants. Generally, the nucleic acids comprise a sequence encoding at least one domain or region associated with an eosinophil biochemical pathway function or associated with activated eosinophils. And, generally, corresponding domains or regions of polypeptides of the invention have at least a five amino acid fragment encoded by one of SEQ NOS: 1-71. Both the nucleic acids and the polypeptides of the invention can be used as probes, targets, or elements of numerous methods for identifying agents or compositions useful in the treatment of asthma or in methods for diagnosing or identifying eosinophil-related disorders in humans and mammals.