The present invention relates to highly selective phosphodiesterase (PDE) enzyme inhibitors and to their use in pharmaceutical articles of manufacture. In particular, the present invention relates to potent inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase type 5 (PDE5) that when incorporated into a pharmaceutical product at about 1 to about 20 mg unit dosage are useful for the treatment of sexual dysfunction.
申请公布号
WO0066099(A2)
申请公布日期
2000.11.09
申请号
WO2000US11129
申请日期
2000.04.26
申请人
LILLY ICOS LLC;PULLMAN, WILLIAM, ERNEST;WHITAKER, JOHN, STEVEN